This document updates the previous 1996 guidelines and is the fourth from this combined group. Related StoriesGenetic carrier screening: an interview with Don Hardison, CEO of Great Begin GeneticsDeaths from avoidable risk factors: an interview with Dr Ali Mokdad, IHMEHigh blood circulation pressure, smoking, and poor dietary behaviors are greatest risk factors for deathAccording to Bonita Falkner, MD, chair of the working group, The solid association of high blood pressure with obesity and the marked upsurge in the prevalence of childhood obesity suggest that both hypertension and prehypertension are becoming a significant ailment in the young.This study by co-workers and Heitman compares the expenses and effectiveness of these two approaches to screening, using assumed prevalences of cancers and polyps among average-risk people 50 to 74 years of age. They found that screening 100 000 sufferers with CT colonography would cost $2.3 million more than with colonoscopy, and would prevent 3.8 fatal perforations – – but simultaneously, this method would result in 4.1 cancer-related deaths from polyps not seen with CT, which would later become malignant. New systems are attractive always. Because CT colonography will not physically invade the body, it has more appeal – – it really is easier for patients to accept even. Its cost, however, is much higher, and its benefit is only slightly less than when colonoscopy can be used..