Though they are interlocked Actually, only one of these is active at the same time in processing their substrate, arachidonic acid – that prostaglandins, the fatty mediators of pain, inflammation, and heart attacks – are formed. The molecular structures of COX-1 and COX-2 are similar remarkably, but a delicate variation in their framework permits the construction of medicines that are selective in their inhibition for COX -2. For this study the researchers created a novel genetic mouse model that mimics the physiology of COX-2 inhibition. The investigators demonstrated that the COX-1:COX-2 partnership, or heterodimer, appears to play a critical function in the transformation that occurs in the arteries of recently born mice, shortly after birth, the closing of the ductus arterious namely.Kaiser Family Foundation. Copyright 2008 Advisory Board Organization and Kaiser Family Foundation. All rights reserved.. Blue Care Systems of Michigan abandons its try to purchase PHP of Mid-Michigan Decision to Abandon Offer Follows Justice Department’s Decision to Problem the Acquisition Blue Cross Blue Shield of Michigan’s subsidiary, Blue Care Systems of Michigan, abandoned it is try to purchase Physicians Wellness Plan of Mid-Michigan following the Division of Justice informed the firms that it would document an antitrust lawsuit to block the acquisition.